Interstrand cross links
WebApr 9, 1999 · Summary. This chapter deals with the interstrand cross-links in cisplatin- or transplatin-modified DNA and focuses on three main aspects: the formation of the interstrand cross-links, the distortions induced in the DNA double helix and the potential use of the interstrand cross-linking reaction in the context of antisense and antigene … WebDNA interstrand cross-links induced by the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine Nature Communications March 26, 2024 Other authors
Interstrand cross links
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WebDNA interstrand cross-linking (ICL) agents are an important group of cytotoxic drugs with the capability of binding covalently between two strands of DNA, thereby preventing vital … WebJan 28, 2024 · DNA interstrand cross-links (ICLs) are among the most cytotoxic form of DNA damage a cell will experience [1, 2].The study of the cellular response to ICLs has substantial implications, from basic biology to a better understanding human disease and in drug development.
WebApr 10, 2024 · Interstrand cross-links (ICLs) from various endogenous and environmental sources covalently tether the opposite strands of DNA and pose a major obstacle to … WebDuring eukaryotic DNA interstrand cross-link (ICL) repair, cross-links are resolved (“unhooked”) by nucleolytic incisions surrounding the lesion. In vertebrates, ICL repair is …
WebDuring eukaryotic DNA interstrand cross-link (ICL) repair, cross-links are resolved (“unhooked”) by nucleolytic incisions surrounding the lesion. In vertebrates, ICL repair is triggered when replication forks collide with the lesion, leading to FANCI-FANCD2-dependent unhooking and formation of a double-strand break (DSB) intermediate. WebDec 22, 2005 · Interstrand DNA Cross-Links Induced by α,β-Unsaturated Aldehydes Derived from Lipid Peroxidation and Environmental Sources. Accounts of Chemical …
WebWhen HU + ara-C exposure preceded or followed DDP treatment, higher levels of interstrand cross-linking were found at late time points than were seen with DDP alone, suggesting repair inhibition. We conclude that the combination of HU, ara-C, and DDP shows synergistic cytotoxicity, and that this effect may be due in part to inhibition of DDP …
WebOct 21, 2024 · DNA alkylating agents generally kill tumor cells by covalently binding with DNA to form interstrand or intrastrand cross-links. However, in the case of cisplatin, only a few DNA adducts (<1%) are highly toxic irreparable interstrand cross-links. Furthermore, cisplatin is rapidly detoxified by high levels of intracellular thiols such as glutathione … clay pot in ovenWebExtension of the primer in cross-linked substrate P, lacking the duplex region on the 3’-side of the cross-link was similarly stalled at the cross-link. Overall, the results provided evidence that the dA-3’ddR5p cross-link was stable against the powerful strand-separating properties ( 73 ) of the helicase-polymerase activity of the bacteriophage ϕ29 DNA … down one bourbon menuWebThe DNA double helix is generally broken down by these DNA cross-links, which also make DNA replication and transcription more difficult and cause the cell to enter cell cycle arrest mode ... and it mostly takes the form of intra or interstrand crosslinks, crosslinks between DNA bases and proteins, single-strand breaks, double-strand ... down on luckWebApr 10, 2024 · Interstrand cross-links (ICLs) from various endogenous and environmental sources covalently tether the opposite strands of DNA and pose a major obstacle to normal DNA metabolism (3, 4).The cytotoxicity of cross-linking agents makes them particularly effective as antitumor drugs ().Because ICLs damage both strands of DNA, repair of … clay pot kharadiWebJan 24, 2024 · Interstrand DNA cross-linking 1,N2-deoxyguanosine adducts derived from α,β-unsaturated aldehydes: structure–function relationships. In The Chemical Biology of … down one louisville kyWebSep 27, 2024 · The FA/BRCA pathway is involved in melphalan-induced DNA interstrand cross-link repair and accounts for melphalan resistance in multiple myeloma cells. Blood 2005, 106, 698–705. [Google Scholar] Clauson, C.; Scharer, O.D.; Niedernhofer, L. Advances in understanding the complex mechanisms of DNA interstrand cross-link … down on lawWebDNA interstrand cross-links (ICL) can be induced both by natural products (e.g., psoralens with UVA) and by chemical agents, some of which are used in chemotherapy (e.g., Carboplatin and mitomycin C). Here, we report the formation of ICL by UV radiation in brominated DNA, but only for very specific conformations. The quantum yields for strand … clay pot in the bible