Irf7 mouse

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August undefined, 2024

WebJun 19, 2024 · To elucidate pDC immunomodulatory functions, we developed a mouse model in which IRF7 signaling is restricted to pDC. Despite undetectable levels of IFN-I protein, pDC-restricted IRF7 signaling controlled both viruses and was sufficient to protect mice from lethal CHIKV infection. Early pDC IRF7-signaling resulted in amplification of … WebInterferon regulatory receptor 7 (IRF7) is a transcription factor involved in the activation of the type I interferon (IFN) response upon pathogenic infection [3-4]. IRF7 has been implicated downstream of several pattern recognition receptors (PRRs), including TLRs, RLRs, and DNA sensors [2].

IRF7-Knockout IFN Reporter Raw 264.7 Macrophages InvivoGen

WebMouse Immunogen Partial IRF7 recombinant protein (127-503 a.a.) Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA) … WebUsing the International Mouse Strain Resource Mouse lines carrying: Irf7 tm1Ttg mutation (2 available); any Irf7 mutation (16 available) ♀ phenotype observed in females diagram of bat wing

The role of interferon regulatory factor 7 in the pathogenicity and ...

WebIRF7 is a lymphoid-specific factor, which is constitutively expressed in the cytoplasm in B cells, pDCs and monocytes in the spleen, thymus, and peripheral blood lymphocytes, and … WebOct 18, 2024 · Interferon regulatory factor 7 (IRF7) is the main transcriptional regulator of type I IFN, and it is crucial for the induction of IFNα/β and the type I IFN-dependent immune response. In this... WebImmunohistochemistry (Paraffin) analysis of IRF7 in paraffin-embedded mouse heart tissue. The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes.The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with IRF7 Recombinant ... cinnamon k rend

(PDF) The role of interferon regulatory factor 7 in the …

Irf7 - PrimePCR Assay and Template Life Science Bio-Rad

WebRestoration of IRF7 in tumor cells isolated from metastatic mouse primary mammary tumors restored the ability to secrete IFN and reduced the metastatic burden in a breast cancer tumor mouse model [165]. Decreased IRF7 expression levels were found to correlate with increased metastatic events in human breast cancer, supporting the notion that ... WebPrimePCR™ Template for SYBR® Green Assay: Irf7, Mouse Reaction: 200 x 20 µl reactions desalted Gene-specific synthetic DNA template designed to give a positive real-time PCR … diagram of biliary treeWebSep 10, 2024 · In mouse embryonic fibroblasts (MEFs), the potent induction of both IFN-α and IFN-β at various time points after herpes simplex virus (HSV)-1 or vesicular stomatitis virus infection was markedly blocked in the absence of IRF7, whereas IRF3 deficiency showed much attenuated effects, especially for IFN-α . cinnamon kitchen port talbot menu

"WebJul 25, 2024 · By performing mass-spectrometry analysis of IRF3 and IRF7 isolated from cells treated with a SIRT1 inhibitor, we identified SIRT1-specific lysine-deacetylation sites and confirmed this result by... " - Irf7 mouse

Irf7 mouse

Plasmacytoid dendritic cells control dengue and Chikungunya …

WebIRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling. There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established. For Research Use Only. WebPhospho-IRF-7 (Ser437/438) (D6M2I) Rabbit mAb (Mouse Specific) recognizes endogenous levels of mouse IRF-7 protein when dually phosphorylated at Ser437 and Ser438. This …

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WebInterferon regulatory factor 7 (IRF7) is the main transcriptional regulator of type I IFN, and it is crucial for the induction of IFNα/β and the type I IFN-dependent immune response. In this study, we focused on the role of IRF7 in the pathogenicity and immunogenicity of RABV using an IRF7 -/- mouse model. WebImmunohistochemistry-Paraffin: IRF7 Antibody (SC0617) [NBP2-67634] - Analysis of paraffin-embedded mouse liver tissue using anti-IRF7 antibody. Counter stained with hematoxylin. Flow Cytometry: IRF7 Antibody (SC0617) [NBP2-67634] - Analysis of Jurkat cells with IRF7 antibody at 1/50 dilution (red) compared with an unlabelled control (cells ...

WebJul 7, 2024 · It remains possible that IRF7, a homolog of IRF3, compensates for the loss of IRF3 and explains the IRF3-independent resistance to HSV-1 that we observe. ... Mouse primary microglia cells and ... WebJul 14, 2016 · IRF3-5D, an active form of IRF3, and IRF7Δ247–467, a constitutively active form of IRF7 were constructed as previously described using pFLAG-IRF3, and pFLAG-IRF7 plasmids as templates 38,39,40 ...

WebApr 7, 2005 · Consistently, Irf7-/- mice are more vulnerable than Myd88-/- mice to viral infection, and this correlates with a marked decrease in serum IFN levels, indicating the … http://www.informatics.jax.org/allele/allgenoviews/MGI:3577089

WebAug 21, 2024 · IRF-7 Antibody (G-8): sc-74472 IRF-7 Antibody (G-8) is a mouse monoclonal IgG 2a κ IRF-7 antibody, cited in 26 publications, provided at 200... IRF-7 Antibody (G-8) is …

IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes. In particular, IRF7 regulates many interferon-alpha genes. Constitutive expression of IRF7 is largely restricted to lymphoid tissue, largely plasmacytoid dendritic cells, whereas IRF7 is inducible in many tissues. Multiple IRF7 tra… diagram of biliary systemWebIRF7 Antibodies Antibodies that detect IRF7 can be used in several scientific applications, including Western Blot, Immunohistochemistry, Flow Cytometry, Immunocytochemistry … diagram of bays and headlandsWebApr 13, 2024 · RNA sequencing analysis of IRF7 CRISPRa and CRISPRi- DF-1 cells revealed the specificity of CRISPRa and CRISPRi-based targeted transcriptional regulation with minimal off-target effects. ... Cox, T.; Melvin, D.; Wang, X.; Bradley, A.; Liu, P. Chromosomal transposition of PiggyBac in mouse embryonic stem cells. Proc. Natl. Acad. Sci. USA … diagram of bifold doorWebJan 10, 2024 · IRF7 is the key transcription factor which induces IFNα expression 9, leading to a second wave of type I IFN release. Since IFNα signals via the IFNAR this leads to a positive feedback loop that... cinnamon kitchen offersWebIn this study, we analyzed the role of IRF3 and IRF7 for the host response to IAV infections in Irf3-/-, Irf7-/-, and Irf3-/-Irf7-/- knockout mice. While the absence of IRF3 had only a … cinnamon labs south korea supplementsWebMay 21, 2024 · By combining DNA microarray and genomic data analyses to predict DNA binding motifs, we identified the transcription factor Interferon Regulatory Factor 7 (IRF7) as a possible regulator of genes related to adipocyte hypertrophy. cinnamon kitchen in devonshire square cinnamon lake apartments waukegan